1415/10 | Tocris Bioscience 1415/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1415/10

catalog :

1415/10

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Müller E, Speth M, Christopoulos P, Lunde A, Avdagic A, Øynebråten I, et al. Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation. Front Immunol. 2018;9:2520 pubmed publisher
Staunton C, Barrett Jolley R, Djouhri L, Thippeswamy T. Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. Exp Physiol. 2018;103:535-544 pubmed publisher
Kuen J, Darowski D, Kluge T, Majety M. Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model. PLoS ONE. 2017;12:e0182039 pubmed publisher
Clark A, Gruber Schoffnegger D, Drdla Schutting R, Gerhold K, Malcangio M, SandkÃ¼hler J. Selective activation of microglia facilitates synaptic strength. J Neurosci. 2015;35:4552-70 pubmed publisher
Gross G, Hsu A, Pfeiffer A, Nithipatikom K. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 2013;59:20-9 pubmed publisher
Gresa Arribas N, Viéitez C, Dentesano G, Serratosa J, Saura J, Solà C. Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS ONE. 2012;7:e45227 pubmed publisher
Al Shalmani S, Suri S, Hughes D, Kroon P, Needs P, Taylor M, et al. Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. Br J Pharmacol. 2011;162:1485-97 pubmed publisher
Tsuda M, Toyomitsu E, Kometani M, Tozaki Saitoh H, Inoue K. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med. 2009;13:3251-9 pubmed publisher
Ashrafpour H, Huang N, Neligan P, Forrest C, Addison P, Moses M, et al. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol. 2004;286:H946-54 pubmed

product information

master code :

1415

SKU :

1415/10

product name :

1400W dihydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent, highly selective iNOS inhibitor

target :

iNOS Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

250.17

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 u M respectively). Cell-permeable and active in vivo . Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.

top caption :

Potent, highly selective iNOS inhibitor

extended description :

Potent, highly selective iNOS inhibitor

chemical name text :

N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride

formula :

C10H15N3.2HCl

formula text :

C10H15N3.2HCl

cas num :

214358-33-5

USD :

157 USD

product details :

Potent, highly selective iNOS inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage