product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1414/1G
catalog :
1414/1G
quantity :
1 g
price :
114 USD
more info or order :
citations: 17
Reference
Bali Z, Bruszt N, Tadepalli S, Csurgyók R, Nagy L, Tompa M, et al. Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. Front Pharmacol. 2019;10:73 pubmed publisher
Cai Y, Ford C. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell Rep. 2018;25:3148-3157.e3 pubmed publisher
Chou D, Peng H, Lin T, Lai C, Hsieh M, Wen Y, et al. (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology. 2018;139:1-12 pubmed publisher
Herrera Rincon C, Pai V, Moran K, Lemire J, Levin M. The brain is required for normal muscle and nerve patterning during early Xenopus development. Nat Commun. 2017;8:587 pubmed publisher
Lecrux C, Sandoe C, Neupane S, Kropf P, Toussay X, Tong X, et al. Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci. 2017;37:1518-1531 pubmed publisher
Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed publisher
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
Rahman M, Tanaka N, Usui K, Kawahara S. Role of Muscarinic Acetylcholine Receptors in Serial Feature-Positive Discrimination Task during Eyeblink Conditioning in Mice. PLoS ONE. 2016;11:e0147572 pubmed publisher
Parent M, Amarante L, Swanson K, Laubach M. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Front Behav Neurosci. 2015;9:284 pubmed publisher
Shin J, Adrover M, Wess J, Alvarez V. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2015;112:8124-9 pubmed publisher
Saunders A, Granger A, Sabatini B. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. elife. 2015;4: pubmed publisher
Bali Z, Inkeller J, Csurgyók R, Bruszt N, Horváth H, Hernádi I. Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models. Behav Brain Res. 2015;278:404-10 pubmed publisher
Marcott P, Mamaligas A, Ford C. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014;84:164-176 pubmed publisher
Chuhma N, Mingote S, Moore H, Rayport S. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Neuron. 2014;81:901-12 pubmed publisher
Field R, Gossen A, Cunningham C. Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci. 2012;32:6288-94 pubmed publisher
Higley M, Gittis A, Oldenburg I, Balthasar N, Seal R, Edwards R, et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE. 2011;6:e19155 pubmed publisher
Chuhma N, Choi W, Mingote S, Rayport S. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience. 2009;164:1068-83 pubmed publisher
product information
master code :
1414
SKU :
1414/1G
product name :
Scopolamine hydrobromide
unit size :
1 g
description :
Non-selective muscarinic antagonist
target :
Non-selective mAChR Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
384.27
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Scopolamine hydrobromide is a non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
top caption :
Non-selective muscarinic antagonist
extended description :
Non-selective muscarinic antagonist
chemical name text :
( ,S)- -(Hydroxymethyl)benzeneacetic acid (1 ,2 ,4 ,5 ,7 )-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide
formula :
C17H21NO4.HBr
formula text :
C17H21NO4.HBr
cas num :
114-49-8
USD :
114 USD
product details :
Non-selective muscarinic antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK