Chromanol 293B | Tocris Bioscience 1412 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Chromanol 293B

catalog :

1412

quantity :

10 mg (also 50 mg)

price :

179 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Inagaki A, Hayashi M, Andharia N, Matsuda H. Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch. 2019;471:313-327 pubmed publisher
Yu C, Ai T, Weiss J, Chen P. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. PLoS ONE. 2014;9:e96691 pubmed publisher
Neal A, Taylor H, Millar I, Kibble J, White S, Robson L. Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol. 2011;589:3595-609 pubmed publisher
McCallum L, Pierce S, England S, Greenwood I, Tribe R. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. J Cell Mol Med. 2011;15:577-86 pubmed publisher
Gage S, Kobertz W. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol. 2004;124:759-71 pubmed

product information

brand :

Tocris

master code :

1412

SKU :

1412/10

product name :

Chromanol 293B

description :

IKs blocker. Also blocks ICFTR

target :

Voltage-gated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

324.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 u M). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 u M). . Enantiomer also available.

catalog number base :

1412

product keywords :

IKs blockers blocks ICFTR Potassium KV Channels voltage-gated voltage-dependent K+ Cl- chloride Chromanol293B Voltage-Gated Potassium Channels CFTR 1412,

extended description :

IKs blocker. Also blocks ICFTR

chemical name text :

trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

formula :

C 15 H 20 N 2 O 4 S

formula text :

C15H20N2O4S

cas num :

163163-23-3

2020 USD :

172

2021 USD :

179 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage