YM 022 | Tocris Bioscience 1408/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YM 022

catalog :

1408/10

quantity :

10 mg (also 50 mg)

price :

228 USD

citations: 4

Reference
Saia R, Mestriner F, Bertozi G, Cunha F, Carnio E. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages. Mediators Inflamm. 2014;2014:896029 pubmed publisher
Wagner K, Roeder Z, DesRochers K, Buhler A, Heinricher M, Cleary D. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla. Neuroscience. 2013;238:29-38 pubmed publisher
Marshall T, Herman D, Largent Milnes T, Badghisi H, Zuber K, Holt S, et al. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E? in the spinal cord. Pain. 2012;153:86-94 pubmed publisher
Karson M, Whittington K, Alger B. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. Neuropharmacology. 2008;54:117-28 pubmed

product information

brand :

Tocris

master code :

1408

SKU :

1408/10

product name :

YM 022

target :

CCK2 Receptor Antagonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

516.6

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

YM 022 is an extremely potent and highly selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.

extended description :

Highly potent, selective non-peptide CCK2 antagonist

chemical name text :

(R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N -(3-methylphenyl)-urea

formula :

C 32 H 28 N 4 O 3

formula text :

C32H28N4O3

cas num :

145084-28-2

USD :

228 USD

product details :

Highly potent, selective non-peptide CCK2 antagonist

storage :

Store at RT