product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Trichostatin A
catalog :
1406
quantity :
1 mg
price :
201 USD
more info or order :
citations: 8
Reference
Lu Y, Stuart J, Talbot Cooper C, Agrawal Singh S, Huntly B, Smid A, et al. Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;116:11997-12006 pubmed publisher
Parira T, Figueroa G, Granado S, Napuri J, Castillo Chabeco B, Nair M, et al. Trichostatin A Shows Transient Protection from Chronic Alcohol-Induced Reactive Oxygen Species (ROS) Production in Human Monocyte-Derived Dendritic Cells. J Alcohol Drug Depend. 2018;6: pubmed publisher
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed publisher
Franklin A, Rusche J, McMahon L. Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein. Neurobiol Learn Mem. 2014;114:193-7 pubmed publisher
Biernacka K, Uzoh C, Zeng L, Persad R, Bahl A, Gillatt D, et al. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. Endocr Relat Cancer. 2013;20:741-51 pubmed publisher
Xia M, Huang R, Sakamuru S, Alcorta D, Cho M, Lee D, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013;14:638-47 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Kobori A, Bamba S, Imaeda H, Ban H, Tsujikawa T, Saito Y, et al. Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. World J Gastroenterol. 2010;16:2355-61 pubmed
product information
brand :
Tocris
master code :
1406
SKU :
1406/1
product name :
Trichostatin A
description :
Potent histone deacetylase inhibitor
target :
Class I Histone Deacetylases Inhibitors
category :
Small Molecules
unit size :
1 mg
purity :
98%
observed molecular weight :
302.37
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.
catalog number base :
1406
product keywords :
Histone deacetylase inhibitors inhibits HDAC Deacetylases TrichostatinA stem cells epigenetics Stem Cell Reprogramming Autophagy Non-selective HDACs Non-Selective HDACs 1406,
extended description :
Potent histone deacetylase inhibitor
chemical name text :
(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
formula :
C 17 H 22 N 2 O 3
formula text :
C17H22N2O3
cas num :
58880-19-6
2020 USD :
193
2021 USD :
201 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK