1406/1 | Tocris Bioscience 1406/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1406/1

catalog :

1406/1

quantity :

1 mg

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Lu Y, Stuart J, Talbot Cooper C, Agrawal Singh S, Huntly B, Smid A, et al. Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;116:11997-12006 pubmed publisher
Parira T, Figueroa G, Granado S, Napuri J, Castillo Chabeco B, Nair M, et al. Trichostatin A Shows Transient Protection from Chronic Alcohol-Induced Reactive Oxygen Species (ROS) Production in Human Monocyte-Derived Dendritic Cells. J Alcohol Drug Depend. 2018;6: pubmed publisher
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed publisher
Franklin A, Rusche J, McMahon L. Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein. Neurobiol Learn Mem. 2014;114:193-7 pubmed publisher
Biernacka K, Uzoh C, Zeng L, Persad R, Bahl A, Gillatt D, et al. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. Endocr Relat Cancer. 2013;20:741-51 pubmed publisher
Xia M, Huang R, Sakamuru S, Alcorta D, Cho M, Lee D, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013;14:638-47 pubmed publisher
Serrat N, Pereira Lopes S, Comalada M, Lloberas J, Celada A. Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophages. Eur J Immunol. 2012;42:3028-37 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Kobori A, Bamba S, Imaeda H, Ban H, Tsujikawa T, Saito Y, et al. Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. World J Gastroenterol. 2010;16:2355-61 pubmed

product information

master code :

1406

SKU :

1406/1

product name :

Trichostatin A

unit size :

1 mg

description :

Potent histone deacetylase inhibitor

target :

Class I Histone Deacetylases Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

302.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington s disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo. Trichostatin A enhances CRISPR-Cas9 gene editing of human induced pluripotent stem cells (iPSCs).

top caption :

Potent histone deacetylase inhibitor

extended description :

Potent histone deacetylase inhibitor

chemical name text :

(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

formula :

C17H22N2O3

formula text :

C17H22N2O3

cas num :

58880-19-6

USD :

265 USD

product details :

Potent histone deacetylase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage