FPL 64176 | Tocris Bioscience 1403 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FPL 64176

catalog :

1403

quantity :

10 mg (also 50 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Zhong W, Chebolu S, Darmani N. Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol. 2018;834:157-168 pubmed publisher
Armstrong G, Drapeau P. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. J Neurosci. 2013;33:1741-52 pubmed publisher
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
Zhang J, Bal M, Bierbower S, Zaika O, Shapiro M. AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. J Neurosci. 2011;31:7199-211 pubmed publisher
Landstrom A, Kellen C, Dixit S, van Oort R, Garbino A, Weisleder N, et al. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011;4:214-23 pubmed publisher
Large R, Hollywood M, Sergeant G, Thornbury K, Bourke S, Levick J, et al. Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol. 2010;299:C1180-94 pubmed publisher

image

image 1 :

Cat.No. 1403 - FPL 64176 C22H21NO3 CAS No. 120934-96-5

product information

brand :

Tocris

master code :

1403

SKU :

1403/10

product name :

FPL 64176

description :

Potent CaV1.x activator

target :

Voltage-gated Calcium Channel Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

347.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

catalog number base :

1403

product keywords :

Potent activator Ca2+ channels L-type Calcium CaV Channels voltage-gated voltage-dependent FPL64176 Cav1.x Channels 1403, Voltage-gated calcium channel activator, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel

extended description :

Potent CaV1.x activator

chemical name text :

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester

formula :

C 22 H 21 NO 3

formula text :

C22H21NO3

cas num :

120934-96-5

2020 USD :

145

2021 USD :

150 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage