product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1403/10
catalog :
1403/10
quantity :
10 mg
price :
194 USD
more info or order :
citations: 6
Reference
Zhong W, Chebolu S, Darmani N. Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol. 2018;834:157-168 pubmed publisher
Armstrong G, Drapeau P. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. J Neurosci. 2013;33:1741-52 pubmed publisher
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
Zhang J, Bal M, Bierbower S, Zaika O, Shapiro M. AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. J Neurosci. 2011;31:7199-211 pubmed publisher
Landstrom A, Kellen C, Dixit S, van Oort R, Garbino A, Weisleder N, et al. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011;4:214-23 pubmed publisher
Large R, Hollywood M, Sergeant G, Thornbury K, Bourke S, Levick J, et al. Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol. 2010;299:C1180-94 pubmed publisher
image
image 1 :
Tocris Bioscience 1403/10 image 1
Cat.No. 1403 - FPL 64176 C22H21NO3 CAS No. 120934-96-5
product information
master code :
1403
SKU :
1403/10
product name :
FPL 64176
unit size :
10 mg
description :
Potent CaV1.x activator
target :
Cav1.x Channel Activators
category :
Small Molecules
purity :
99%
observed molecular weight :
347.41
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
FPL 64176 is a potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.
top caption :
Potent CaV1.x activator
extended description :
Potent CaV1.x activator
chemical name text :
2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
formula :
C22H21NO3
formula text :
C22H21NO3
cas num :
120934-96-5
USD :
194 USD
product details :
Potent CaV1.x activator
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK