1402/10 | Tocris Bioscience 1402/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1402/10

catalog :

1402/10

quantity :

10 mg

price :

393 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, et al. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell. 2019;179:687-702.e18 pubmed publisher
Zhang W, Du L, Zheng X, Chen X, Shi C, Chen B, et al. Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance. J Biol Chem. 2018;293:1030-1039 pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Silpanisong J, Kim D, Williams J, Adeoye O, Thorpe R, Pearce W. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1. Am J Physiol Cell Physiol. 2017;313:C207-C218 pubmed publisher
Lukjanenko L, Jung M, Hegde N, Perruisseau Carrier C, Migliavacca E, Rozo M, et al. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med. 2016;22:897-905 pubmed publisher
Eden D, Siegbahn A, Mokhtari D. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets. Diabetologia. 2015;58:2563-72 pubmed publisher
Mans R, Warmus B, Smith C, McMahon L. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol. 2014;112:2388-97 pubmed publisher
Nguyen T, Kwon S, Hong S, Ma S, Jung Y, Hwang J, et al. Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology. 2014;39:2414-22 pubmed publisher
Williams K, Ghosh R, Giridhar P, Gu G, Case T, Belcher S, et al. Inhibition of stathmin1 accelerates the metastatic process. Cancer Res. 2012;72:5407-17 pubmed publisher
Engel F, Hsieh P, Lee R, Keating M. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A. 2006;103:15546-51 pubmed
Schlemper V, Medeiros R, Ferreira J, Campos M, Calixto J. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro. Br J Pharmacol. 2005;145:740-50 pubmed

product information

master code :

1402

SKU :

1402/10

product name :

SB 203580 hydrochloride

unit size :

10 mg

description :

Selective inhibitor of p38 MAPK; water-soluble

target :

p38 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

413.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 and PKB . Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

top caption :

Selective inhibitor of p38 MAPK; water-soluble

extended description :

Selective inhibitor of p38 MAPK; water-soluble

chemical name text :

4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride

formula :

C21H16FN3OS.HCl

formula text :

C21H16FN3OS.HCl

cas num :

869185-85-3

USD :

393 USD

product details :

Selective inhibitor of p38 MAPK; water-soluble

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage