1398/10 | Tocris Bioscience 1398/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1398/10

catalog :

1398/10

quantity :

10 mg

price :

248 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Du Z, Chen H, Liu H, Lu J, Qian K, Huang C, et al. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 2015;6:6626 pubmed publisher
Goonesekere N, Wang X, Ludwig L, Guda C. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS ONE. 2014;9:e93046 pubmed publisher

product information

master code :

1398

SKU :

1398/10

product name :

Kenpaullone

unit size :

10 mg

description :

GSK-3 inhibitor; also inhibits cdks

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

327.18

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Kenpaullone is a GSK-3beta inhibitor (IC50 = 0.23 M). Also inhibits cyclin dependent kinases (cdks) in the sub micromolar range (reported IC50 values are 0.4, 0.68-7 and 0.85 M for cdk1, cdk2 and cdk5, respectively). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.

top caption :

GSK-3 inhibitor; also inhibits cdks

extended description :

GSK-3 inhibitor; also inhibits cdks

chemical name text :

9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one

formula :

C16H11BrN2O

formula text :

C16H11BrN2O

cas num :

142273-20-9

USD :

248 USD

product details :

GSK-3 inhibitor; also inhibits cdks

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage