1397/10 | Tocris Bioscience 1397/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1397/10

catalog :

1397/10

quantity :

10 mg

price :

357 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Kurz J, Barthelmes J, Blum L, Ulshöfer T, Wegner M, Ferreirós N, et al. Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes. Sci Rep. 2019;9:747 pubmed publisher
Ferland D, Darios E, Neubig R, Sjögren B, Truong N, Torres R, et al. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 2017;88:30-41 pubmed publisher
Mace E, Gunesch J, Dixon A, Orange J. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat Commun. 2016;7:12171 pubmed publisher
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed publisher
Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, et al. Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015;14:19 pubmed publisher
Pham H, Chen M, Takahashi H, King J, Reber H, HINES O, et al. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012;41:1306-15 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher
Eum S, Andras I, Hennig B, Toborek M. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol. 2009;240:299-305 pubmed publisher
Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E. Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. FASEB J. 2009;23:1459-69 pubmed publisher
Alonso Magdalena P, Ropero A, Carrera M, Cederroth C, Baquie M, Gauthier B, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE. 2008;3:e2069 pubmed publisher
Lee Y, Kayyali U, Sousa A, Rajan T, Lechleider R, Day R. Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Am J Respir Cell Mol Biol. 2007;37:485-93 pubmed
Zhang J, Kalyankrishna S, Wislez M, Thilaganathan N, Saigal B, Wei W, et al. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol. 2007;170:366-76 pubmed

product information

master code :

1397

SKU :

1397/10

product name :

PP 1

unit size :

10 mg

description :

Potent, selective Src family kinase inhibitor

target :

Src Family Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

281.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PP 1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

top caption :

Potent, selective Src family kinase inhibitor

extended description :

Potent, selective Src family kinase inhibitor

chemical name text :

1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

formula :

C16H19N5

formula text :

C16H19N5

cas num :

172889-26-8

USD :

357 USD

product details :

Potent, selective Src family kinase inhibitor

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage