MRS 1334 | Tocris Bioscience 1385 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRS 1334

catalog :

1385

quantity :

10 mg (also 50 mg)

price :

179 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Alsharif K, Thomas M, Judge H, Khan H, Prince L, Sabroe I, et al. Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascul Pharmacol. 2015;71:201-7 pubmed publisher
Corriden R, Self T, Akong Moore K, Nizet V, Kellam B, Briddon S, et al. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013;14:726-32 pubmed publisher
Lee S, Kim J, Kim J, Jang Y, Kim J, Park Y, et al. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Korean J Anesthesiol. 2012;63:340-5 pubmed publisher
Varani K, Padovan M, Vincenzi F, Targa M, Trotta F, Govoni M, et al. A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. Arthritis Res Ther. 2011;13:R197 pubmed publisher
Guerreiro S, Toulorge D, Hirsch E, Marien M, Sokoloff P, Michel P. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008;74:980-9 pubmed publisher
Eltzschig H, Thompson L, Karhausen J, Cotta R, Ibla J, Robson S, et al. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004;104:3986-92 pubmed

product information

brand :

Tocris

master code :

1385

SKU :

1385/10

product name :

MRS 1334

description :

Potent, highly selective hA3 antagonist

target :

Adenosine A3 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

522.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and 100 u M at rat A1 and rat A2A receptors.

catalog number base :

1385

product keywords :

Potent selective hA3 antagonists Receptors adenosines MRS1334 Adenosine A3 Receptors 1385,

extended description :

Potent, highly selective hA3 antagonist

chemical name text :

1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester

formula :

C 31 H 26 N 2 O 6

formula text :

C31H26N2O6

cas num :

192053-05-7

2020 USD :

173

2021 USD :

179 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage