L-152,804 | Tocris Bioscience 1382 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-152,804

catalog :

1382

quantity :

10 mg (also 50 mg)

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Businaro R, Scaccia E, Bordin A, Pagano F, Corsi M, Siciliano C, et al. Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep. 2018;8:14365 pubmed publisher
Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, TralhÃ£o P, et al. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 2015;7: pubmed publisher
Long M, Zhou J, Li D, Zheng L, Xu Z, Zhou S. Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor. PLoS ONE. 2015;10:e0126714 pubmed publisher
Aveleira C, Botelho M, Carmo Silva S, Pascoal J, Ferreira Marques M, NÃ³brega C, et al. Neuropeptide Y stimulates autophagy in hypothalamic neurons. Proc Natl Acad Sci U S A. 2015;112:E1642-51 pubmed publisher
Santos Carvalho A, Elvas F, Alvaro A, Ambrósio A, Cavadas C. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Cell Death Dis. 2013;4:e636 pubmed publisher
Ferreira R, Santos T, Viegas M, Cortes L, Bernardino L, Vieira O, et al. Neuropeptide Y inhibits interleukin-1?-induced phagocytosis by microglial cells. J Neuroinflammation. 2011;8:169 pubmed publisher
Ferreira R, Xapelli S, Santos T, Silva A, Cristóvão A, Cortes L, et al. Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia. J Biol Chem. 2010;285:41921-34 pubmed publisher
Woldbye D, Angehagen M, Gøtzsche C, Elbrønd Bek H, Sørensen A, Christiansen S, et al. Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures. Brain. 2010;133:2778-88 pubmed publisher
Ortiz A, Milardo L, DeCarr L, Buckholz T, Mays M, Claus T, et al. A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents. J Pharmacol Exp Ther. 2007;323:692-700 pubmed

product information

brand :

Tocris

master code :

1382

SKU :

1382/10

product name :

L-152,804

description :

Potent, selective non-peptide NPY Y5 receptor antagonist

target :

NPY Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

366.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo .

catalog number base :

1382

product keywords :

Potent selective non-peptide NPY Y5 antagonists Neuropeptide Y Receptors L152804 neuropeptides NPY Receptors 1382,

extended description :

Potent, selective non-peptide NPY Y5 receptor antagonist

chemical name text :

5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione

formula :

C 23 H 26 O 4

formula text :

C23H26O4

cas num :

6508-43-6

2020 USD :

216

2021 USD :

225 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage