GW 5074 | Tocris Bioscience 1381 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 5074

catalog :

1381

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Li C, Wood D, Huang J, Bhatia S. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013;13:1969-78 pubmed publisher
Cooper O, Seo H, Andrabi S, Guardia Laguarta C, Graziotto J, Sundberg M, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012;4:141ra90 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed publisher
Kim S, Thanh Thuy T, Lee J, Ro J, Bae Y, Kong Y, et al. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. Exp Mol Med. 2009;41:277-87 pubmed publisher
Magro F, Fraga S, Soares da Silva P. Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma. Br J Pharmacol. 2005;145:93-103 pubmed
Magro F, Fraga S, Ribeiro T, Soares da Silva P. Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol. 2004;142:1281-92 pubmed

product information

brand :

Tocris

master code :

1381

SKU :

1381/10

product name :

GW 5074

description :

Potent, selective c-Raf1 kinase inhibitor

target :

Raf Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

520.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Also binds mutant huntingtin (mHTT). Decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington's disease.

catalog number base :

1381

product keywords :

Potent selective c-Raf1 kinases inhibitors inhibits GW5074 mHTT huntingtin huntingtons disease Raf Kinase 1381,

extended description :

Potent, selective c-Raf1 kinase inhibitor

chemical name text :

3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one

formula :

C 15 H 8 Br 2 INO 2

formula text :

C15H8Br2INO2

cas num :

220904-83-6

2020 USD :

187

2021 USD :

195 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage