1381/10 | Tocris Bioscience 1381/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1381/10

catalog :

1381/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Kaiserman J, O Hara B, Garabian K, Lukacher A, Haley S, Atwood W. The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway. MBio. 2023;:e0358322 pubmed publisher
Li C, Wood D, Huang J, Bhatia S. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013;13:1969-78 pubmed publisher
Cooper O, Seo H, Andrabi S, Guardia Laguarta C, Graziotto J, Sundberg M, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012;4:141ra90 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed publisher
Kim S, Thanh Thuy T, Lee J, Ro J, Bae Y, Kong Y, et al. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. Exp Mol Med. 2009;41:277-87 pubmed publisher
Magro F, Fraga S, Soares da Silva P. Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma. Br J Pharmacol. 2005;145:93-103 pubmed
Magro F, Fraga S, Ribeiro T, Soares da Silva P. Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol. 2004;142:1281-92 pubmed

product information

master code :

1381

SKU :

1381/10

product name :

GW 5074

unit size :

10 mg (also 50 mg)

description :

Potent, selective c-Raf1 kinase inhibitor

target :

Raf Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

520.94

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). GW 5074 displays 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW 5074 binds mutant huntingtin (mHTT) and decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington s disease. Brain penetrant.

top caption :

Potent, selective c-Raf1 kinase inhibitor

extended description :

Potent, selective c-Raf1 kinase inhibitor

chemical name text :

3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one

formula :

C15H8Br2INO2

formula text :

C15H8Br2INO2

cas num :

220904-83-6

USD :

245 USD

product details :

Potent, selective c-Raf1 kinase inhibitor

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage