product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1378/10
catalog :
1378/10
quantity :
10 mg (also 50 mg)
price :
331 USD
more info or order :
citations: 3
Reference
Fransen P, Van Hove C, Leloup A, Martinet W, De Meyer G, Lemmens K, et al. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. PLoS ONE. 2015;10:e0121634 pubmed publisher
Garland C, Smirnov S, Bagher P, Lim C, Huang C, Mitchell R, et al. TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol. 2015;172:1114-23 pubmed publisher
Fike C, Aschner J, Kaplowitz M, Zhang Y, Madden J. Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ. 2013;3:551-63 pubmed publisher
product information
master code :
1378
SKU :
1378/10
product name :
Levcromakalim
unit size :
10 mg (also 50 mg)
description :
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
target :
Inward Rectifier Potassium Channel Activators
category :
Small Molecules
purity :
99%
observed molecular weight :
286.33
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
top caption :
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
extended description :
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
chemical name text :
(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
formula :
C16H18N2O3
formula text :
C16H18N2O3
cas num :
94535-50-9
USD :
331 USD
product details :
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
alt names :
BRL 38227
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK