product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Cromakalim
catalog :
1377
quantity :
10 mg (also 50 mg)
price :
205 USD
more info or order :
citations: 7
Reference
Whidden M, Basgut B, Kirichenko N, Erdos B, Tumer N. Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem. 2016;20:58-64 pubmed publisher
Mehmood M, Munir S, Khalid U, Asrar M, Gilani A. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. BMC Complement Altern Med. 2015;15:75 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Lasker G, Pankey E, Frink T, Zeitzer J, Walter K, Kadowitz P. The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol. 2013;304:H1670-9 pubmed publisher
Mathias R, von der Weid P. Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G623-34 pubmed publisher
Institoris A, Snipes J, Katakam P, Domoki F, Boda K, Bari F, et al. Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2011;300:H2080-7 pubmed publisher
Erdos B, Miller A, Busija D. Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2002;283:H2472-7 pubmed
product information
brand :
Tocris
master code :
1377
SKU :
1377/10
product name :
Cromakalim
description :
Kir6 (KATP) channel opener
target :
Inward Rectifier Potassium Channel Activators
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
286.33
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo . . Active Enantiomer also available.
catalog number base :
1377
product keywords :
KATP channel openers Potassium KIR Kir6 Channels Inward Rectifier K+ BRL34915 BRL 34915 Inward rectifier Potassium Channels 1377,
extended description :
Kir6 (KATP) channel opener
chemical name text :
trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
formula :
C 16 H 18 N 2 O 3
formula text :
C16H18N2O3
cas num :
94470-67-4
2020 USD :
199
2021 USD :
205 USD
alt names :
BRL 34915
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK