SB 218795 | Tocris Bioscience 1376 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 218795

catalog :

1376

quantity :

10 mg (also 50 mg)

price :

174 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
LiÃ±Ã¡n Rico A, Wunderlich J, Enneking J, Tso D, Grants I, Williams K, et al. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2Xâ‚, P2Xâ‚‚, P2Xâ‚ƒ channels, P2Y and Aâ‚ƒ metabotropic receptors in neurotransmission. Neuropharmacology. 2015;95:83-99 pubmed publisher
Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
Valero M, Fagundes D, Grasa L, Arruebo M, Plaza M, Murillo M. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin. 2011;32:487-94 pubmed publisher
Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, et al. The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1?, IL-23, and TNF-like 1A expression by monocytes. J Immunol. 2011;186:4175-82 pubmed publisher

product information

brand :

Tocris

master code :

1376

SKU :

1376/10

product name :

SB 218795

description :

Potent, selective non-peptide NK3 antagonist

target :

NK3 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

396.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.

catalog number base :

1376

product keywords :

Potent selective non-peptide NK3 antagonists Tachykinin Receptors Neurokinin SB218795 NK3 Receptor 1376,

extended description :

Potent, selective non-peptide NK3 antagonist

chemical name text :

(R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid

formula :

C 25 H 20 N 2 O 3

formula text :

C25H20N2O3

cas num :

174635-53-1

2020 USD :

168

2021 USD :

174 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage