product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1372/10
catalog :
1372/10
quantity :
10 mg (also 50 mg)
price :
205 USD
more info or order :
citations: 7
Reference
Nagata M, Yokooji T, Nakai T, Miura Y, Tomita T, Taogoshi T, et al. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 2019;9:16438 pubmed publisher
Salzer I, Gantumur E, Yousuf A, Boehm S. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channels. Neuropharmacology. 2016;110:277-286 pubmed publisher
Watanabe H, Nakano T, Saito R, Akasaka D, Saito K, Ogasawara H, et al. Serotonin Improves High Fat Diet Induced Obesity in Mice. PLoS ONE. 2016;11:e0147143 pubmed publisher
Gerhold K, Drdla Schutting R, Honsek S, Forsthuber L, Sandkühler J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35:9580-94 pubmed publisher
Hernandez L, Gregerson K, Horseman N. Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Am J Physiol Endocrinol Metab. 2012;302:E1009-15 pubmed publisher
Wouters M, Roeder J, Tharayil V, Stanich J, Strege P, Lei S, et al. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009;284:21177-84 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
product information
master code :
1372
SKU :
1372/10
product name :
SB 204741
unit size :
10 mg (also 50 mg)
description :
Potent, selective 5-HT2B antagonist
target :
5-HT2B Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
286.35
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.
top caption :
Potent, selective 5-HT2B antagonist
extended description :
Potent, selective 5-HT2B antagonist
chemical name text :
N-(1-Methyl-1H-indolyl-5-yl)-N -(3-methyl-5-isothiazolyl)urea
formula :
C14H14N4OS
formula text :
C14H14N4OS
cas num :
152239-46-8
USD :
205 USD
product details :
Potent, selective 5-HT2B antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK