Sphingosine-1-phosphate | Tocris Bioscience 1370 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sphingosine-1-phosphate

catalog :

1370

quantity :

1 mg

price :

192 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed publisher
Hübner K, Cabochette P, Diéguez Hurtado R, Wiesner C, Wakayama Y, Grassme K, et al. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun. 2018;9:4860 pubmed publisher
Hill R, Hoffman B, Morita T, Campos S, Lumpkin E, Brem R, et al. The signaling lipid sphingosine 1-phosphate regulates mechanical pain. elife. 2018;7: pubmed publisher
Krispin S, Stratman A, Melick C, Stan R, Malinverno M, Gleklen J, et al. Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. Arterioscler Thromb Vasc Biol. 2018;38:353-362 pubmed publisher
Camp N, Lee K, Cherry A, Wacker Mhyre J, Kountz T, Park J, et al. Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res. 2016;105:13-21 pubmed publisher
Hu Y, Li M, Gothert J, Gomez R, Sequeira Lopez M. Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development. J Am Soc Nephrol. 2016;27:1984-95 pubmed publisher
Kho D, Macdonald C, Johnson R, Unsworth C, O Carroll S, du Mez E, et al. Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time. Biosensors (Basel). 2015;5:199-222 pubmed publisher
Hannedouche S, Beck V, Leighton Davies J, Beibel M, Roma G, Oakeley E, et al. Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. J Biol Chem. 2013;288:27434-43 pubmed publisher
Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, et al. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS ONE. 2013;8:e63718 pubmed publisher
Pierre S, Häusler J, Birod K, Geisslinger G, Scholich K. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J. 2004;23:3031-40 pubmed

product information

brand :

Tocris

master code :

1370

SKU :

1370/1

product name :

Sphingosine-1-phosphate

description :

Endogenous agonist at S1P1-5

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

379.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2 3 -cyclic-GMP-AMP (cGAMP).

catalog number base :

1370

product keywords :

Endogenous agonists S1P1 S1P2 S1P3 S1P4 S1P5 Receptors EDG Sphingosine-1-Phosphate GPR3 GPR6 GPR12 cGAMP transports transporters VRAC LRRC8 Sphingosine-1-phosphate Receptors STING-Dependent Signaling 1370,

extended description :

Endogenous agonist at S1P1-5

chemical name text :

(E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol

formula :

C 18 H 38 NO 5 P

formula text :

C18H38NO5P

cas num :

26993-30-6

2020 USD :

188

2021 USD :

192 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage