Geldanamycin | Tocris Bioscience 1368 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Geldanamycin

catalog :

1368

quantity :

1 mg

price :

378 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Yang Y, Wang W, Li M, Gao Y, Zhang W, Huang Y, et al. NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits. Cell Mol Life Sci. 2019;76:381-395 pubmed publisher
Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed publisher
Chung Davidson Y, Yeh C, Bussy U, Li K, Davidson P, Nanlohy K, et al. Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis. BMC Dev Biol. 2015;15:47 pubmed publisher
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
Barker C, McNamara A, Rackstraw S, Nelson D, White M, Watson A, et al. Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage. Nucleic Acids Res. 2006;34:1148-57 pubmed

product information

brand :

Tocris

master code :

1368

SKU :

1368/1

product name :

Geldanamycin

description :

Selective Hsp90 inhibitor

target :

HSP90 Inhibitors

category :

Small Molecules

unit size :

1 mg

main entrez gene id :

3320

purity :

98%

observed molecular weight :

560.64

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 u M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

catalog number base :

1368

product keywords :

Selective Hsp90 inhibitors inhibits Heat Shock Protein 90 antibiotics Hsp90 Antibiotics Stem Cell Signaling Cancer Stem Cells 1368,

extended description :

Selective Hsp90 inhibitor

chemical name text :

9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

formula :

C 29 H 40 N 2 O 9

formula text :

C29H40N2O9

cas num :

30562-34-6

2020 USD :

363

2021 USD :

378 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage