1368/1 | Tocris Bioscience 1368/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1368/1

catalog :

1368/1

quantity :

1 mg

price :

422 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Yang Y, Wang W, Li M, Gao Y, Zhang W, Huang Y, et al. NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits. Cell Mol Life Sci. 2019;76:381-395 pubmed publisher
Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed publisher
Chung Davidson Y, Yeh C, Bussy U, Li K, Davidson P, Nanlohy K, et al. Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis. BMC Dev Biol. 2015;15:47 pubmed publisher
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
Hurrell T, Outhoff K. The in vitro influences of epidermal growth factor and heregulin-β1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma. Cancer Cell Int. 2013;13:97 pubmed publisher
Barker C, McNamara A, Rackstraw S, Nelson D, White M, Watson A, et al. Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage. Nucleic Acids Res. 2006;34:1148-57 pubmed

product information

master code :

1368

SKU :

1368/1

product name :

Geldanamycin

unit size :

1 mg

description :

Selective Hsp90 inhibitor

target :

HSP90 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

560.64

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Geldanamycin is a selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 u M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

top caption :

Selective Hsp90 inhibitor

extended description :

Selective Hsp90 inhibitor

chemical name text :

9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

formula :

C29H40N2O9

formula text :

C29H40N2O9

cas num :

30562-34-6

USD :

422 USD

product details :

Selective Hsp90 inhibitor

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage