ZM 39923 hydrochloride | Tocris Bioscience 1367/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZM 39923 hydrochloride

catalog :

1367/10

quantity :

10 mg (also 50 mg)

price :

245 USD

citations: 5

Reference
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Koscsó B, Csóka B, Kókai E, Németh Z, Pacher P, Virag L, et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013;94:1309-15 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Vidro Kotchan E, Yendluri B, Le Thai T, Tsin A. NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGF?. Curr Eye Res. 2011;36:370-8 pubmed publisher
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1367

SKU :

1367/10

product name :

ZM 39923 hydrochloride

description :

Potent, selective JAK3 inhibitor

target :

JAK Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Desiccate at +4°C

observed molecular weight :

367.92

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t = 36 mins, pH 7.43, 25 C) to form ZM 449829 (Cat. No. 1366).

product keywords :

Potent selective JAK3 inhibitors inhibits Janus Activated Kinase JAK Kinases ZM39923 hydrochloride HCl AstraZeneca 58753-54-1 JAK JAK Kinase 1367,

extended description :

Potent, selective JAK3 inhibitor

chemical name text :

3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride

formula :

C23H25NO.HCl

formula text :

C23H25NO.HCl

cas num :

1021868-92-7

USD :

242

USD 2025 :

245 USD

product details :

Potent, selective JAK3 inhibitor