ZM 449829 | Tocris Bioscience 1366/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZM 449829

catalog :

1366/10

quantity :

10 mg (also 50 mg)

price :

191 USD

citations: 4

Reference
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed publisher
Lu Y, Zhou J, Xu C, Lin H, Xiao J, Wang Z, et al. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2008;21:305-14 pubmed publisher
Gross E, Hsu A, Gross G. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol. 2006;291:H827-34 pubmed

product information

brand :

Tocris

master code :

1366

SKU :

1366/10

product name :

ZM 449829

description :

Potent, selective JAK3 inhibitor

target :

JAK Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

182.22

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ZM 449829 is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.

extended description :

Potent, selective JAK3 inhibitor

chemical name text :

1-(2-Naphthalenyl)-2-propen-1-one

formula :

C 13 H 10 O

formula text :

C13H10O

cas num :

6/6/52

USD :

181

USD 2023 :

191 USD

product details :

Potent, selective JAK3 inhibitor

storage :

Desiccate at -20°C