1364/1G | Tocris Bioscience 1364/1G product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1364/1G

catalog :

1364/1G

quantity :

1 g

price :

160 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
Khan A, Bloom J, Faridmoayer E, Smith D. Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J. 2016;16:164-72 pubmed publisher
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, et al. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain. 2014;10:45 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher

product information

master code :

1364

SKU :

1364/1G

product name :

Colchicine

unit size :

1 g

description :

Inhibitor of tubulin

target :

Microtubule Binding Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

399.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF- receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.

top caption :

Inhibitor of tubulin

extended description :

Inhibitor of tubulin

chemical name text :

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

formula :

C22H25NO6

formula text :

C22H25NO6

cas num :

64-86-8

USD :

160 USD

product details :

Inhibitor of tubulin

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage