product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PD 123319 ditrifluoroacetate
catalog :
1361
quantity :
10 mg (also 50 mg)
price :
231 USD
more info or order :
citations: 22
Reference
Moreno Santos B, Marchi Coelho C, Costa Ferreira W, Crestani C. Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav Brain Res. 2021;397:112947 pubmed publisher
Domińska K, Okła P, Kowalska K, Habrowska Górczyńska D, Urbanek K, Ochedalski T, et al. Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci Rep. 2018;8:15772 pubmed publisher
Raffai G, Lombard J. Angiotensin-(1-7) Selectively Induces Relaxation and Modulates Endothelium-Dependent Dilation in Mesenteric Arteries of Salt-Fed Rats. J Vasc Res. 2016;53:105-118 pubmed
Gu H, Xie Z, Li T, Zhang S, Lai C, Zhu P, et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep. 2016;6:19840 pubmed publisher
Fan Y, Wang L, Liu C, Zhu H, Zhou L, Wang Y, et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Int J Clin Exp Pathol. 2015;8:2505-14 pubmed
Skorska A, von Haehling S, Ludwig M, Lux C, Gaebel R, Kleiner G, et al. The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function. J Cell Mol Med. 2015;19:1975-85 pubmed publisher
Porter A, Pillidge K, Grabowska E, Stanford S. The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder. Eur Neuropsychopharmacol. 2015;25:512-21 pubmed publisher
Chang K, Nayak R, Roy S, Perumbeti A, Wellendorf A, Bezold K, et al. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial ATâ‚‚R and cytoskeletal dysregulation. Nat Commun. 2015;6:5914 pubmed publisher
Santollo J, Whalen P, Speth R, Clark S, Daniels D. Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1396-404 pubmed publisher
Speth R, Carrera E, Bretón C, Linares A, Gonzalez Reiley L, Swindle J, et al. Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PLoS ONE. 2014;9:e105762 pubmed publisher
Speth R, Vento P, Carrera E, Gonzalez Reily L, Linares A, Santos K, et al. Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain. Brain Res. 2014;1583:132-40 pubmed publisher
Santiago J, McNaughton L, Koleini N, Ma X, Bestvater B, Nickel B, et al. High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling. PLoS ONE. 2014;9:e97281 pubmed publisher
Nemoto W, Nakagawasai O, Yaoita F, Kanno S, Yomogida S, Ishikawa M, et al. Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice. Mol Pain. 2013;9:38 pubmed publisher
Chakrabarty A, Liao Z, Smith P. Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain. J Pain. 2013;14:1053-65 pubmed publisher
Cruz D, Koishi A, Taniguchi J, Li X, Milan Bonotto R, No J, et al. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis. 2013;7:e2073 pubmed publisher
Hong N, Garvin J. Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. Hypertension. 2012;60:765-9 pubmed publisher
Tsai C, Chan J, Hsu K, Chang A, Chan S. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS ONE. 2012;7:e33527 pubmed publisher
Hasin T, Elhanani O, Abassi Z, Hai T, Aronheim A. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol. 2011;106:175-87 pubmed publisher
Curato C, Slavic S, Dong J, Skorska A, Altarche Xifró W, Miteva K, et al. Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury. J Immunol. 2010;185:6286-93 pubmed publisher
Bourassa E, Fang X, Li X, Sved A, Speth R. AT₁ angiotensin II receptor and novel non-AT₁, non-AT₂ angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat. Brain Res. 2010;1359:98-106 pubmed publisher
Santiago J, Ma X, McNaughton L, Nickel B, Bestvater B, Yu L, et al. Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes. Cardiovasc Res. 2011;89:139-47 pubmed publisher
Benkirane K, Amiri F, Diep Q, El Mabrouk M, Schiffrin E. PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Am J Physiol Heart Circ Physiol. 2006;290:H390-7 pubmed
product information
brand :
Tocris
master code :
1361
SKU :
1361/10
product name :
PD 123319 ditrifluoroacetate
description :
Potent and selective non-peptide AT2 antagonist
target :
Angiotensin AT2 Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
736.67
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
catalog number base :
1361
product keywords :
Potent selective non-peptide AT2 antagonists Receptors Angiotensin PD123319 ditrifluoroacetate Angiotensin AT2 Receptors 1361,
extended description :
Potent and selective non-peptide AT2 antagonist
chemical name text :
(6S)1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
formula :
C 31 H 32 N 4 O 3 .2CF 3 CO 2 H
formula text :
C31H32N4O3.2CF3CO2H
cas num :
136676-91-0
2020 USD :
220
2021 USD :
231 USD
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK