product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PD 123319 ditrifluoroacetate
catalog :
1361/10
quantity :
10 mg
price :
293 USD
more info or order :
citations: 25
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Raffai G, Lombard J. Angiotensin-(1-7) Selectively Induces Relaxation and Modulates Endothelium-Dependent Dilation in Mesenteric Arteries of Salt-Fed Rats. J Vasc Res. 2016;53:105-118 pubmed
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Fan Y, Wang L, Liu C, Zhu H, Zhou L, Wang Y, et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Int J Clin Exp Pathol. 2015;8:2505-14 pubmed
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Porter A, Pillidge K, Grabowska E, Stanford S. The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder. Eur Neuropsychopharmacol. 2015;25:512-21 pubmed publisher
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Speth R, Vento P, Carrera E, Gonzalez Reily L, Linares A, Santos K, et al. Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain. Brain Res. 2014;1583:132-40 pubmed publisher
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Benkirane K, Amiri F, Diep Q, El Mabrouk M, Schiffrin E. PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Am J Physiol Heart Circ Physiol. 2006;290:H390-7 pubmed
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product information
brand :
Tocris
catalog number base :
1361
SKU :
1361/10
product name :
PD 123319 ditrifluoroacetate
units size :
10 mg
description :
Potent and selective non-peptide AT2 antagonist
target :
Angiotensin AT2 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
736.67
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
5
details of functionality :
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
top caption :
Potent and selective non-peptide AT2 antagonist
extended description :
Potent and selective non-peptide AT2 antagonist
chemical name text :
(6S)1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
formula :
C31H32N4O3.2CF3CO2H
formula text :
C31H32N4O3.2CF3CO2H
cas num :
136676-91-0
USD :
293 USD
product details :
Potent and selective non-peptide AT2 antagonist
storage :
Store at -20°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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