Calyculin A | Tocris Bioscience 1336 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Calyculin A

catalog :

1336

quantity :

100 ug

price :

524 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Burdyga A, Surdo N, Monterisi S, Di Benedetto G, Grisan F, Penna E, et al. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 2018;115:E6497-E6506 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Fabbrizi M, Meyer B, Misri S, Raj S, Zobel C, Hallahan D, et al. Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy. Cell Death Dis. 2018;9:492 pubmed publisher
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
Chazeau A, Garcia M, CzÃ¶ndÃ¶r K, Perrais D, Tessier B, Giannone G, et al. Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines. Mol Biol Cell. 2015;26:859-73 pubmed publisher
Bhattachariya A, TurczyÅ„ska K, Grossi M, NordstrÃ¶m I, Buckbinder L, Albinsson S, et al. PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep. 2014;2: pubmed publisher
Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, et al. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci. 2014;127:216-29 pubmed publisher
Colpaert E, Levent A, Lefebvre R. Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA/Rho-kinase independent Ca2+ desensitisation. Br J Pharmacol. 2005;144:588-94 pubmed

product information

brand :

Tocris

master code :

1336

SKU :

1336/100U

product name :

Calyculin A

description :

Protein phosphatase 1 and 2A inhibitor

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

unit size :

100 ug

purity :

98%

observed molecular weight :

1009.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays 10,000,000-fold selectivity over PP2B and PP2C.

catalog number base :

1336

product keywords :

Protein phosphatase 1 2A inhibitors inhibits Calcineurin Ser/Thr Phosphatases PP1 PP2A CalyculinA Protein Ser/Thr Phosphatases 1336,

extended description :

Protein phosphatase 1 and 2A inhibitor

chemical name text :

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl

formula :

C 50 H 81 N 4 O 15 P

formula text :

C50H81N4O15P

cas num :

101932-71-2

2020 USD :

499

2021 USD :

524 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage