1336/10U | Tocris Bioscience 1336/10U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1336/10U

catalog :

1336/10U

quantity :

10 ug

price :

309 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Burdyga A, Surdo N, Monterisi S, Di Benedetto G, Grisan F, Penna E, et al. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 2018;115:E6497-E6506 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Fabbrizi M, Meyer B, Misri S, Raj S, Zobel C, Hallahan D, et al. Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy. Cell Death Dis. 2018;9:492 pubmed publisher
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
Chazeau A, Garcia M, CzÃ¶ndÃ¶r K, Perrais D, Tessier B, Giannone G, et al. Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines. Mol Biol Cell. 2015;26:859-73 pubmed publisher
Bhattachariya A, TurczyÅ„ska K, Grossi M, NordstrÃ¶m I, Buckbinder L, Albinsson S, et al. PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep. 2014;2: pubmed publisher
Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, et al. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci. 2014;127:216-29 pubmed publisher
Colpaert E, Levent A, Lefebvre R. Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA/Rho-kinase independent Ca2+ desensitisation. Br J Pharmacol. 2005;144:588-94 pubmed

product information

master code :

1336

SKU :

1336/10U

product name :

Calyculin A

unit size :

10 ug

description :

Protein phosphatase 1 and 2A inhibitor

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

purity :

90%

observed molecular weight :

1009.18

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays 10,000,000-fold selectivity over PP2B and PP2C. . Note: This product is typically prepared in DMSO.

top caption :

Protein phosphatase 1 and 2A inhibitor

extended description :

Protein phosphatase 1 and 2A inhibitor

chemical name text :

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl

formula :

C50H81N4O15P

formula text :

C50H81N4O15P

cas num :

101932-71-2

USD :

309 USD

product details :

Protein phosphatase 1 and 2A inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage