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company name :
Tocris Bioscience
product type :
chemical
product name :
1334/100U
catalog :
1334/100U
quantity :
100 ug
price :
322 USD
more info or order :
citations: 61
Reference
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product information
master code :
1334
SKU :
1334/100U
product name :
Bafilomycin A1
unit size :
100 ug
description :
H+-ATPase (vacuolar) inhibitor
target :
H+-ATPase Inhibitors
category :
Small Molecules
purity :
95%
observed molecular weight :
622.84
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Bafilomycin A1 is a highly potent, selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation. Bafilomycin A1 accelerates wound healing in db/db mice. Low dose Bafilomycin A1 attenuates patient-derived CD34+CD19+ leukemia stem cells (LSC) and inhibits LSC proliferation in an animal model. Bafilomycin A1 impairs Zika virus infection in vitro .
top caption :
H+-ATPase (vacuolar) inhibitor
extended description :
H+-ATPase (vacuolar) inhibitor
chemical name text :
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
formula :
C35H58O9
formula text :
C35H58O9
cas num :
88899-55-2
USD :
322 USD
product details :
H+-ATPase (vacuolar) inhibitor
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK