Chelerythrine chloride | Tocris Bioscience 1330/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Chelerythrine chloride

catalog :

1330/5

quantity :

5 mg

price :

200 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Livingstone R, Elder M, Barrett M, Westlake C, Peppercorn K, Tate W, et al. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 2019;12:198 pubmed publisher
Martín Segura A, Casadomé Perales Á, Fazzari P, Mas J, Artigas L, Valls R, et al. Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. Front Neurol. 2019;10:675 pubmed publisher
Li S, Huo M, Wu X, Huang Y, Wang L, Zhang X, et al. Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep. 2017;7:15317 pubmed publisher
Ortinski P, Briand L, Pierce R, Schmidt H. Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons. Neuropharmacology. 2015;92:80-9 pubmed publisher
Morelli M, Amantini C, Nabissi M, Liberati S, Cardinali C, Farfariello V, et al. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer. 2014;14:921 pubmed publisher
Liu M, Zhuo M. Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 2014;10:1 pubmed publisher
Gosselin R, Meylan P, Decosterd I. Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation. Front Cell Neurosci. 2013;7:251 pubmed publisher
Cho J, Zushida K, Shumyatsky G, Carlezon W, Meloni E, Bolshakov V. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 2012;32:14165-77 pubmed publisher
Most P, Lerchenmüller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, et al. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res. 2013;112:66-78 pubmed publisher
Jin W, Yu L. Involvement of protein kinase C in morphine tolerance at spinal levels of rats. ACS Chem Neurosci. 2010;1:122-8 pubmed publisher
Mockett B, Guevremont D, Wutte M, Hulme S, Williams J, Abraham W. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. J Neurosci. 2011;31:7380-91 pubmed publisher
Chen H, Liao P, Chan M. mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci. 2011;18:19 pubmed publisher
Fuortes M, Rico M, Merlin L. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Epilepsia. 2010;51:1633-7 pubmed publisher
Xu X, Wang P, Zou X, Li D, Fang L, Gong K, et al. The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin. Exp Neurol. 2010;222:93-107 pubmed publisher
Xie C, Wang D. Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension. 2009;54:1298-305 pubmed publisher
Song J, Eyster K, Kost C, Kjellsen B, Martin D. Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction. Cardiovasc Res. 2010;85:614-21 pubmed publisher
Xu X, Wang P, Zou X, Li D, Fang L, Lin Q. Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. J Neurosci Res. 2009;87:482-94 pubmed publisher

product information

brand :

Tocris

catalog number base :

1330

SKU :

1330/5

product name :

Chelerythrine chloride

units size :

5 mg

description :

Cell-permeable protein kinase C inhibitor

target :

Protein Kinase C Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

383.83

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 u M) or Bad proteins and stimulates apoptosis.

top caption :

Cell-permeable protein kinase C inhibitor

extended description :

Cell-permeable protein kinase C inhibitor

chemical name text :

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

formula :

C21H18ClNO4

formula text :

C21H18ClNO4

cas num :

3895-92-9

USD :

200 USD

product details :

Cell-permeable protein kinase C inhibitor

storage :

Desiccate at -20Â°C

more info or order :

Tocris Bioscience product webpage