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company name :
Tocris Bioscience
product type :
chemical
product name :
1329/1
catalog :
1329/1
quantity :
1 mg
price :
272 USD
more info or order :
citations: 34
Reference
Babola T, Kersbergen C, Wang H, Bergles D. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. elife. 2020;9: pubmed publisher
Jourdain P, Rothenfusser K, Ben Adiba C, Allaman I, Marquet P, Magistretti P. Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection. Sci Rep. 2018;8:13472 pubmed publisher
Li Q, Navakkode S, Rothkegel M, Soong T, Sajikumar S, Korte M. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114:5527-5532 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Tyser R, Miranda A, Chen C, Davidson S, Srinivas S, Riley P. Calcium handling precedes cardiac differentiation to initiate the first heartbeat. elife. 2016;5: pubmed publisher
Zhang P, Zhang G, Zhou W, Weng S, Yang X, Zhong Y. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells. Sci Rep. 2016;6:28938 pubmed publisher
Zhang J, Cheng K, Lai D, Kong L, Shen M, Yi F, et al. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel. Int J Clin Exp Pathol. 2015;8:10239-49 pubmed
Dobson K, Jackson C, Balakrishnan S, Bellamy T. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. PLoS ONE. 2015;10:e0125974 pubmed publisher
Zhu M, Sung T, O Driscoll K, Koh S, Sanders K. Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal. Am J Physiol Cell Physiol. 2015;308:C608-20 pubmed publisher
Al Dera H, Callaghan B, Brock J. Modified cytoplasmic Ca2+ sequestration contributes to spinal cord injury-induced augmentation of nerve-evoked contractions in the rat tail artery. PLoS ONE. 2014;9:e111804 pubmed publisher
Nordman J, Kabbani N. Microtubule dynamics at the growth cone are mediated by ?7 nicotinic receptor activation of a G?q and IP3 receptor pathway. FASEB J. 2014;28:2995-3006 pubmed publisher
Kyle B, Bradley E, Large R, Sergeant G, McHale N, Thornbury K, et al. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists. Am J Physiol Cell Physiol. 2013;305:C609-22 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Naka A, Gruber Schoffnegger D, Sandkühler J. Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons. Pain. 2013;154:1333-42 pubmed publisher
Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle F. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS ONE. 2013;8:e58673 pubmed publisher
Low V, Fiorini Z, Fisher L, Jasoni C. Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner. PLoS ONE. 2012;7:e46999 pubmed publisher
Kim E, Kim D, Kim S, Lee K, Park H, Kim S. Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells. Korean J Physiol Pharmacol. 2011;15:431-6 pubmed publisher
Few A, Nanou E, Watari H, Sullivan J, Scheuer T, Catterall W. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A. 2012;109:E452-60 pubmed publisher
Begum G, Kintner D, Liu Y, Cramer S, Sun D. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem. 2012;120:622-30 pubmed publisher
Xu H, Bae M, Tovar Y Romo L, Patel N, Bandaru V, Pomerantz D, et al. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. J Neurosci. 2011;31:17074-90 pubmed publisher
Zhou J, Alvarez Elizondo M, Botvinick E, George S. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985). 2012;112:627-37 pubmed publisher
Gruol D, Nelson T, Hao C, Michael S, Vukojevic V, Ming Y, et al. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells. Alcohol Clin Exp Res. 2012;36:443-56 pubmed publisher
Li Q, Burrell B. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem. 2011;18:545-53 pubmed publisher
Fernandez Velasco M, Ruiz Hurtado G, Rueda A, Neco P, Mercado Morales M, Delgado C, et al. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS ONE. 2011;6:e20863 pubmed publisher
Kim C, Majdi M, Xia P, Wei K, Talantova M, Spiering S, et al. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Stem Cells Dev. 2010;19:783-95 pubmed publisher
Karwatsky J, Ma L, Dong F, Zha X. Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling. J Lipid Res. 2010;51:1144-56 pubmed publisher
Huang C, Hsu K. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010;20:982-96 pubmed publisher
Gerich F, Funke F, Hildebrandt B, Fasshauer M, Muller M. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. Pflugers Arch. 2009;458:937-52 pubmed publisher
Luciani D, Gwiazda K, Yang T, Kalynyak T, Bychkivska Y, Frey M, et al. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes. 2009;58:422-32 pubmed publisher
Henrich M, Buckler K. Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons. J Neurophysiol. 2008;100:456-73 pubmed publisher
Dror V, Kalynyak T, Bychkivska Y, Frey M, Tee M, Jeffrey K, et al. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem. 2008;283:9909-16 pubmed publisher
Gascon E, Dayer A, Sauvain M, Potter G, Jenny B, De Roo M, et al. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci. 2006;26:12956-66 pubmed
Dai T, Ramirez Correa G, Gao W. Apelin increases contractility in failing cardiac muscle. Eur J Pharmacol. 2006;553:222-8 pubmed
Larina O, Thorn P. Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses. J Cell Sci. 2005;118:4131-9 pubmed
product information
master code :
1329
SKU :
1329/1
product name :
Ryanodine
unit size :
1 mg
description :
Ca2+ release inhibitor
target :
Ryanodine Receptor Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
493.55
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
top caption :
Ca2+ release inhibitor
extended description :
Ca2+ release inhibitor
chemical name text :
1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
formula :
C25H35NO9
formula text :
C25H35NO9
cas num :
15662-33-6
USD :
272 USD
product details :
Ca2+ release inhibitor
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK