1327/10 | Tocris Bioscience 1327/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1327/10

catalog :

1327/10

quantity :

10 mg (also 50 mg)

price :

224 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Xiong Z, Zhang K, Ishima T, Ren Q, Chang L, Chen J, et al. Comparison of rapid and long-lasting antidepressant effects of negative modulators of α5-containing GABAA receptors and (R)‑ketamine in a chronic social defeat stress model. Pharmacol Biochem Behav. 2018;175:139-145 pubmed publisher
Seifi M, Rodaway S, Rudolph U, Swinny J. GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice. Gastroenterology. 2018;155:852-864.e3 pubmed publisher
Ferando I, Faas G, Mody I. Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci. 2016;19:1197-200 pubmed publisher
Jaiswal M, Keros S, Zhao M, Inan M, Schwartz T, Anderson S, et al. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor Î±4 subunit. Front Cell Neurosci. 2015;9:127 pubmed publisher
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78 pubmed publisher
Drexler B, Zinser S, Huang S, Poe M, Rudolph U, Cook J, et al. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 2013;703:18-24 pubmed publisher
Rüedi Bettschen D, Rowlett J, Rallapalli S, Clayton T, Cook J, Platt D. Modulation of ?5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcohol Clin Exp Res. 2013;37:624-34 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Penatti C, Porter D, Henderson L. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci. 2009;29:12484-96 pubmed publisher

product information

master code :

1327

SKU :

1327/10

product name :

L-655,708

unit size :

10 mg (also 50 mg)

description :

Benzodiazepine inverse agonist; selective for 5-containing GABAA receptors

target :

Benzodiazepine Inverse Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

341.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-655,708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the 5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing 1, 2, 3 or 6 subunits in combination with 3 and 2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

top caption :

Benzodiazepine inverse agonist; selective for 5-containing GABAA receptors

extended description :

Benzodiazepine inverse agonist; selective for 5-containing GABAA receptors

chemical name text :

11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

formula :

C18H19N3O4

formula text :

C18H19N3O4

cas num :

130477-52-0

USD :

224 USD

product details :

Benzodiazepine inverse agonist; selective for 5-containing GABAA receptors

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage