1325/10 | Tocris Bioscience 1325/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1325/10

catalog :

1325/10

quantity :

10 mg (also 50 mg)

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Ishii K, Sugimura Y. Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug. J Chem Biol. 2015;8:5-9 pubmed publisher
Zacharia J, Mauban J, Raina H, Fisher S, WIER W. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via ?1A- and ?1D-adrenoceptor subtypes. PLoS ONE. 2013;8:e65969 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Cleary L, Slattery J, Bexis S, Docherty J. Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. Br J Pharmacol. 2004;143:745-52 pubmed

product information

master code :

1325

SKU :

1325/10

product name :

RS 100329 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent, subtype-selective 1A antagonist

target :

Adrenergic alpha-1 Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

462.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RS 100329 hydrochloride is a subtype-selective 1A-adrenoceptor antagonist (pKi = 9.6 for human cloned 1A receptors). Displays 126- and 50-fold selectivity over human 1B and 1D receptors respectively. Active in vivo .

top caption :

Potent, subtype-selective 1A antagonist

extended description :

Potent, subtype-selective 1A antagonist

chemical name text :

5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride

formula :

C20H25F3N4O3.HCl

formula text :

C20H25F3N4O3.HCl

cas num :

1215654-26-4

USD :

243 USD

product details :

Potent, subtype-selective 1A antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage