GR 113808 | Tocris Bioscience 1322 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GR 113808

catalog :

1322

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Sengupta J, Mickle A, Kannampalli P, Spruell R, McRorie J, Shaker R, et al. Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM). Neuropharmacology. 2014;79:345-58 pubmed publisher
Mondal A, Aizawa S, Sakata I, Goswami C, Oda S, Sakai T. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS ONE. 2013;8:e60365 pubmed publisher
Beattie D, Armstrong S, Vickery R, Tsuruda P, Campbell C, Richardson C, et al. The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2011;2:25 pubmed publisher
Ptak K, Yamanishi T, Aungst J, Milescu L, Zhang R, Richerson G, et al. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci. 2009;29:3720-37 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed

product information

brand :

Tocris

master code :

1322

SKU :

1322/10

product name :

GR 113808

description :

Potent and selective 5-HT4 antagonist

target :

5-HT4 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

393.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.

catalog number base :

1322

product keywords :

Potent selective 5-HT4 antagonists Serotonin Receptors 5-Hydroxytryptamine GR113808 GlaxoSmithKline GSK 5-HT4 Receptors 1322,

extended description :

Potent and selective 5-HT4 antagonist

chemical name text :

1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester

formula :

C 19 H 27 N 3 O 4 S

formula text :

C19H27N3O4S

cas num :

144625-51-4

2020 USD :

187

2021 USD :

195 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage