1322/10 | Tocris Bioscience 1322/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1322/10

catalog :

1322/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Sengupta J, Mickle A, Kannampalli P, Spruell R, McRorie J, Shaker R, et al. Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM). Neuropharmacology. 2014;79:345-58 pubmed publisher
Mondal A, Aizawa S, Sakata I, Goswami C, Oda S, Sakai T. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS ONE. 2013;8:e60365 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Beattie D, Armstrong S, Vickery R, Tsuruda P, Campbell C, Richardson C, et al. The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2011;2:25 pubmed publisher
Ptak K, Yamanishi T, Aungst J, Milescu L, Zhang R, Richerson G, et al. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci. 2009;29:3720-37 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed

product information

master code :

1322

SKU :

1322/10

product name :

GR 113808

unit size :

10 mg (also 50 mg)

description :

Potent and selective 5-HT4 antagonist

target :

5-HT4 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

393.5

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GR 113808 is a potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.

top caption :

Potent and selective 5-HT4 antagonist

extended description :

Potent and selective 5-HT4 antagonist

chemical name text :

1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester

formula :

C19H27N3O4S

formula text :

C19H27N3O4S

cas num :

144625-51-4

USD :

245 USD

product details :

Potent and selective 5-HT4 antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage