CP 94253 hydrochloride | Tocris Bioscience 1317 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 94253 hydrochloride

catalog :

1317

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
El Mansari M, Lecours M, Blier P. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology (Berl). 2015;232:2343-52 pubmed publisher
Doslikova B, Garfield A, Shaw J, Evans M, Burdakov D, Billups B, et al. 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci. 2013;33:9800-4 pubmed publisher
Eriksson T, Alvarsson A, Stan T, Zhang X, Hascup K, Hascup E, et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry. 2013;18:1096-105 pubmed publisher
Hagan C, McDevitt R, Liu Y, Furay A, Neumaier J. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse. 2012;66:1024-34 pubmed publisher
McDevitt R, Hiroi R, MacKenzie S, Robin N, Cohn A, Kim J, et al. Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior. Biol Psychiatry. 2011;69:780-7 pubmed publisher
Heisler L, Jobst E, Sutton G, Zhou L, Borok E, Thornton Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51:239-49 pubmed

product information

brand :

Tocris

master code :

1317

SKU :

1317/10

product name :

CP 94253 hydrochloride

description :

Potent and selective 5-HT1B agonist

target :

5-HT1B Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

293.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo .

catalog number base :

1317

product keywords :

Potent selective 5-HT1B agonists Serotonin Receptors CP94253 hydrochloride 5-HT1B Receptors 1317,

extended description :

Potent and selective 5-HT1B agonist

chemical name text :

5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride

formula :

C 15 H 19 N 3 O.HCl

formula text :

C15H19N3O.HCl

cas num :

845861-39-4

2020 USD :

203

2021 USD :

210 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage