1316/1 | Tocris Bioscience 1316/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1316/1

catalog :

1316/1

quantity :

1 mg

price :

562 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Patel D, Kuyucak S, Doupnik C. Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels. Biochemistry. 2020;59:836-850 pubmed publisher
Aguilar Sanchez Y, Rodríguez de Yurre A, Argenziano M, Escobar A, Ramos Franco J. Transmural Autonomic Regulation of Cardiac Contractility at the Intact Heart Level. Front Physiol. 2019;10:773 pubmed publisher
Llamosas N, Ugedo L, Torrecilla M. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiol Rep. 2017;5: pubmed publisher
Workman E, Haddick P, Bush K, Dilly G, Niere F, Zemelman B, et al. Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3Î·. Mol Psychiatry. 2015;20:298-310 pubmed publisher
Stott J, Barrese V, Jepps T, Leighton E, Greenwood I. Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension. 2015;65:676-82 pubmed publisher
Marcott P, Mamaligas A, Ford C. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014;84:164-176 pubmed publisher
Chu C, Jin W, Bing Y, Jin Q, Kannan H, Qiu D. Effects of stresscopin on rat hypothalamic paraventricular nucleus neurons in vitro. PLoS ONE. 2013;8:e53863 pubmed publisher
Parsons M, Burt J, Cranford A, Alberto C, Zipperlen K, Hirasawa M. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area. PLoS ONE. 2012;7:e45350 pubmed publisher
Choisy S, James A, Hancox J. Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node. Biochem Biophys Res Commun. 2012;423:496-502 pubmed publisher
Choisy S, Cheng H, Smith G, James A, Hancox J. Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. PLoS ONE. 2012;7:e33448 pubmed publisher
Yi Y, Sung D, Millette C, Sutovsky M, Kennedy C, Sutovsky P, et al. Sperm GIRK2-containing K+ inward rectifying channels participate in sperm capacitation and fertilization. Syst Biol Reprod Med. 2011;57:296-308 pubmed publisher

product information

master code :

1316

SKU :

1316/1

product name :

Tertiapin-Q

unit size :

1 mg

description :

Selective blocker of inward-rectifier K+ channels

target :

Inward Rectifier Potassium Channel Blockers

category :

Peptides

purity :

95%

observed molecular weight :

2452

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Tertiapin-Q is a high affinity blocker for inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin. Tertiapin-Q binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Tertiapin-Q improves heart rate and atrioventricular conduction in a mouse model of bradycardia. Derivative Tertiapin LQ (Cat. No. 4339) also available.

top caption :

Selective blocker of inward-rectifier K+ channels

extended description :

Selective blocker of inward-rectifier K+ channels

formula :

C106H175N35O24S4

formula text :

C106H175N35O24S4

cas num :

910044-56-3

USD :

562 USD

product details :

Selective blocker of inward-rectifier K+ channels

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage