product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
WY 14643
catalog :
1312
quantity :
10 mg (also 50 mg)
price :
63 USD
more info or order :
citations: 12
Reference
Strand E, Lysne V, Grinna M, Bohov P, Svardal A, Nygård O, et al. Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats. PPAR Res. 2019;2019:8047627 pubmed publisher
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher
Lee J, Lee J, Cho Y. Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med. 2018;7: pubmed publisher
Neuhaus W, Kramer T, Neuhoff A, Gölz C, Thal S, Förster C. Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury. Front Mol Neurosci. 2017;10:149 pubmed publisher
Oruqaj G, Karnati S, Vijayan V, Kotarkonda L, Boateng E, Zhang W, et al. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A. 2015;112:E2048-57 pubmed publisher
Rizvi Y, Mehta C, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol. 2013;59:144-51 pubmed publisher
Puligheddu M, Pillolla G, Melis M, Lecca S, Marrosu F, De Montis M, et al. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS ONE. 2013;8:e64541 pubmed publisher
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher
Mascia P, Pistis M, Justinova Z, Panlilio L, Luchicchi A, Lecca S, et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011;69:633-41 pubmed publisher
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed publisher
Ropero A, Juan Pico P, Rafacho A, Fuentes E, Bermúdez Silva F, Roche E, et al. Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol. 2009;200:127-38 pubmed publisher
Lee G, Kim N, Zhao Z, Cha B, Kim Y. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. Biochem J. 2004;378:983-90 pubmed
product information
brand :
Tocris
master code :
1312
SKU :
1312/10
product name :
WY 14643
description :
Selective PPAR agonist
target :
PPAR alpha Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
323.8
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective PPAR agonist (EC50 values are 0.63, 32 and 100 u M at PPAR , PPAR and PPAR respectively). Negatively inhibits NF- B transcriptional activity and decreases the inflammatory response in vitro and in vivo .
catalog number base :
1312
product keywords :
Selective PPAR PPARalpha agonists Peroxisome-Proliferator Receptors PPARs WY14643 PPARalpha Receptors 1312,
extended description :
Selective PPAR agonist
chemical name text :
[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
formula :
C 14 H 14 ClN 3 O 2 S
formula text :
C14H14ClN3O2S
cas num :
50892-23-4
2020 USD :
61
2021 USD :
63 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK