MK 886 | Tocris Bioscience 1311 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MK 886

catalog :

1311

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Oguh Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, et al. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;: pubmed publisher
Shahid R, Vigna S, Layne A, Romac J, Liddle R. Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol. 2015;1:75-86 pubmed
Rizvi Y, Mehta C, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol. 2013;59:144-51 pubmed publisher
Puligheddu M, Pillolla G, Melis M, Lecca S, Marrosu F, De Montis M, et al. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS ONE. 2013;8:e64541 pubmed publisher
Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013;288:18789-802 pubmed publisher
Eisele P, Salatino S, Sobek J, Hottiger M, Handschin C. The peroxisome proliferator-activated receptor ? coactivator 1?/? (PGC-1) coactivators repress the transcriptional activity of NF-?B in skeletal muscle cells. J Biol Chem. 2013;288:2246-60 pubmed publisher
Scuderi C, Valenza M, Stecca C, Esposito G, Carratu M, Steardo L. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-?. J Neuroinflammation. 2012;9:49 pubmed publisher
Esposito G, Scuderi C, Valenza M, Togna G, Latina V, De Filippis D, et al. Cannabidiol reduces A?-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR? involvement. PLoS ONE. 2011;6:e28668 pubmed publisher
Vigna S, Shahid R, Nathan J, McVey D, Liddle R. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011;40:708-14 pubmed publisher
Mascia P, Pistis M, Justinova Z, Panlilio L, Luchicchi A, Lecca S, et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011;69:633-41 pubmed publisher
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed publisher

image

image 1 :

Cat.No. 1311 - MK 886 C27H34ClNO2S CAS No. 118414-82-7

product information

brand :

Tocris

master code :

1311

SKU :

1311/10

product name :

MK 886

description :

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

target :

Lipoxygenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

472.08

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPAR antagonist (IC50 = 0.5-1 u M). Orally active in vivo .

catalog number base :

1311

product keywords :

Inhibitor 5-lipoxygenase-activating protein FLAP PPAR PPARalpha antagonists inhibitors inhibits Oxygenases Oxidases leukotrienes eicosanoids biosynthesis Peroxisome Proliferator-activated PPARs MK886 L663536 5-LOX L-663,536 Lipoxygenase PPARalpha Receptors Leukotriene and Related Receptors 1311,

extended description :

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

chemical name text :

1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]- , -dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid

formula :

C 27 H 34 ClNO 2 S

formula text :

C27H34ClNO2S

cas num :

118414-82-7

2020 USD :

203

2021 USD :

210 USD

alt names :

L-663,536

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage