MK 886 | Tocris Bioscience 1311/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MK 886

catalog :

1311/10

quantity :

10 mg (also 50 mg)

price :

262 USD

citations: 11

Reference
Oguh Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, et al. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;: pubmed publisher
Shahid R, Vigna S, Layne A, Romac J, Liddle R. Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol. 2015;1:75-86 pubmed
Rizvi Y, Mehta C, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol. 2013;59:144-51 pubmed publisher
Puligheddu M, Pillolla G, Melis M, Lecca S, Marrosu F, De Montis M, et al. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS ONE. 2013;8:e64541 pubmed publisher
Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013;288:18789-802 pubmed publisher
Eisele P, Salatino S, Sobek J, Hottiger M, Handschin C. The peroxisome proliferator-activated receptor ? coactivator 1?/? (PGC-1) coactivators repress the transcriptional activity of NF-?B in skeletal muscle cells. J Biol Chem. 2013;288:2246-60 pubmed publisher
Scuderi C, Valenza M, Stecca C, Esposito G, Carratu M, Steardo L. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-?. J Neuroinflammation. 2012;9:49 pubmed publisher
Esposito G, Scuderi C, Valenza M, Togna G, Latina V, De Filippis D, et al. Cannabidiol reduces A?-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR? involvement. PLoS ONE. 2011;6:e28668 pubmed publisher
Vigna S, Shahid R, Nathan J, McVey D, Liddle R. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011;40:708-14 pubmed publisher
Mascia P, Pistis M, Justinova Z, Panlilio L, Luchicchi A, Lecca S, et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011;69:633-41 pubmed publisher
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed publisher

product information

brand :

Tocris

MasterCode :

1311

SKU :

1311/10

product name :

MK 886

target :

Lipoxygenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

472.08

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPAR antagonist (IC50 = 0.5-1 u M). Orally active in vivo .

extended description :

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

chemical name text :

1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]- , -dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid

formula :

C 27 H 34 ClNO 2 S

formula text :

C27H34ClNO2S

cas num :

118414-82-7

USD :

262 USD

product details :

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

alt names :

L-663,536

storage :

Store at RT