product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1310/5
catalog :
1310/5
quantity :
5 mg
price :
258 USD
more info or order :
citations: 14
Reference
Gaertner S, Auger C, Farooq M, Pollet B, Khemais Benkhiat S, Niazi Z, et al. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. Int J Mol Sci. 2020;21: pubmed publisher
Abdulkareem Z, Gee J, Cox C, Wann K. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol. 2016;173:177-90 pubmed publisher
Chien C, Su M. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biomed Sci. 2015;22:42 pubmed publisher
Kurahashi M, MUTAFOVA YAMBOLIEVA V, Koh S, Sanders K. Platelet-derived growth factor receptor-?-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol. 2014;307:C561-70 pubmed publisher
Coleman N, Brown B, Oliván Viguera A, Singh V, Olmstead M, Valero M, et al. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol. 2014;86:342-57 pubmed publisher
Alpert M, Alford S. Synaptic NMDA receptor-dependent Ca²? entry drives membrane potential and Ca²? oscillations in spinal ventral horn neurons. PLoS ONE. 2013;8:e63154 pubmed publisher
Benton M, Lewis A, Bant J, Raman I. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol. 2013;109:2528-41 pubmed publisher
Hsueh C, Chang P, Hsieh Y, Reher T, Chen P, Lin S. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium. Heart Rhythm. 2013;10:891-8 pubmed publisher
Geier P, Lagler M, Boehm S, Kubista H. Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels. Am J Physiol Cell Physiol. 2011;300:C937-49 pubmed publisher
Lamy C, Goodchild S, Weatherall K, Jane D, Liégeois J, Seutin V, et al. Allosteric block of KCa2 channels by apamin. J Biol Chem. 2010;285:27067-77 pubmed publisher
Oliveira M, Skinner F, Arshadmansab M, Garcia I, Mello C, Knaus H, et al. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res. 2010;1348:187-99 pubmed publisher
Hilgers R, Janssen G, Fazzi G, De Mey J. Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries. J Pharmacol Exp Ther. 2010;333:210-7 pubmed publisher
Giachini F, Carneiro F, Lima V, Carneiro Z, Dorrance A, Webb R, et al. Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats. Transl Res. 2009;154:183-93 pubmed publisher
Szollosi A, Nenquin M, Aguilar Bryan L, Bryan J, Henquin J. Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels. J Biol Chem. 2007;282:1747-56 pubmed
product information
master code :
1310
SKU :
1310/5
product name :
UCL 1684
unit size :
5 mg
description :
Highly potent KCa2 (SK) channel blocker
target :
Ca2+-Activated Potassium Channel Blockers
category :
Small Molecules
purity :
97%
observed molecular weight :
654.44
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.
top caption :
Highly potent KCa2 (SK) channel blocker
extended description :
Highly potent KCa2 (SK) channel blocker
chemical name text :
6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide
formula :
C34H30Br2N4
formula text :
C34H30Br2N4
cas num :
199934-16-2
USD :
258 USD
product details :
Highly potent KCa2 (SK) channel blocker
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK