1305/10 | Tocris Bioscience 1305/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1305/10

catalog :

1305/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Wong A, Chen S, Yang L, Kanagasundaram Y, Crasta K. Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discov. 2018;4:109 pubmed publisher
Drpic D, Almeida A, Aguiar P, Renda F, Damas J, Lewin H, et al. Chromosome Segregation Is Biased by Kinetochore Size. Curr Biol. 2018;28:1344-1356.e5 pubmed publisher
Shrestha R, Conti D, Tamura N, Braun D, Ramalingam R, Cieśliński K, et al. Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun. 2017;8:150 pubmed publisher
Janczar S, Nautiyal J, Xiao Y, Curry E, Sun M, Zanini E, et al. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis. 2017;8:e2955 pubmed publisher
Asteriti I, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, et al. Identification of small molecule inhibitors of the Aurora-A/TPX2 complex. Oncotarget. 2017;8:32117-32133 pubmed publisher
Barr A, Bakal C. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Sci Rep. 2015;5:10564 pubmed publisher
Asraf H, Avunie Masala R, Hershfinkel M, Gheber L. Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol. PLoS ONE. 2015;10:e0129255 pubmed publisher
Floriot S, Vesque C, Rodriguez S, Bourgain Guglielmetti F, Karaiskou A, Gautier M, et al. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle. Nat Commun. 2015;6:6894 pubmed publisher
Habu T, Matsumoto T. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. Springerplus. 2013;2:562 pubmed publisher
Vladimirou E, McHedlishvili N, Gasic I, Armond J, Samora C, Meraldi P, et al. Nonautonomous movement of chromosomes in mitosis. Dev Cell. 2013;27:60-71 pubmed publisher
Kabeche L, Compton D. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature. 2013;502:110-3 pubmed publisher
Corrigan A, Shrestha R, Zulkipli I, Hiroi N, Liu Y, Tamura N, et al. Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle. 2013;12:2643-55 pubmed publisher
Shrestha R, Draviam V. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol. 2013;23:1514-26 pubmed publisher
Lera R, Burkard M. High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells. J Biol Chem. 2012;287:42812-25 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Bartoli K, Jakovljevic J, Woolford J, Saunders W. Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell. 2011;22:3420-30 pubmed publisher
Bassett E, Wood S, Salimian K, Ajith S, Foltz D, Black B. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol. 2010;190:177-85 pubmed publisher
Samoshkin A, Arnaoutov A, Jansen L, Ouspenski I, Dye L, Karpova T, et al. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS ONE. 2009;4:e6831 pubmed publisher
Vijapurkar U, Wang W, Herbst R. Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways. Cancer Res. 2007;67:237-45 pubmed
Chin G, Herbst R. Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint. Mol Cancer Ther. 2006;5:2580-91 pubmed
Trinkle Mulcahy L, Andrews P, Wickramasinghe S, Sleeman J, Prescott A, Lam Y, et al. Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell. 2003;14:107-17 pubmed

product information

master code :

1305

SKU :

1305/10

product name :

Monastrol

unit size :

10 mg (also 50 mg)

description :

Selective inhibitor of mitotic kinesin Eg5

target :

Kinesin Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

292.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 u M).

top caption :

Selective inhibitor of mitotic kinesin Eg5

extended description :

Selective inhibitor of mitotic kinesin Eg5

chemical name text :

1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

formula :

C14H16N2O3S

formula text :

C14H16N2O3S

cas num :

254753-54-3

USD :

246 USD

product details :

Selective inhibitor of mitotic kinesin Eg5

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage