1300/10 | Tocris Bioscience 1300/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1300/10

catalog :

1300/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Tankiewicz Kwedlo A, Hermanowicz J, Pawlak K, Czarnomysy R, Bielawski K, Prokop I, et al. Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer. Int J Mol Sci. 2018;19: pubmed publisher
Colmers P, Bains J. Balancing tonic and phasic inhibition in hypothalamic corticotropin-releasing hormone neurons. J Physiol. 2018;596:1919-1929 pubmed publisher
Wang F, Zhang W, Wang C, Fang X, Cheng H, Liu S, et al. Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-ÎºB pathway. Oncotarget. 2017;8:34099-34110 pubmed publisher
He Y, Zeng M, Yang D, Motro B, NÃºÃ±ez G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016;530:354-7 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Lopez E, Jardin I, Berna Erro A, Bermejo N, Salido G, Sage S, et al. STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets. Cell Signal. 2012;24:1315-22 pubmed publisher
Hart J, Liao L, Yates J, Vogt P. Essential role of Stat3 in PI3K-induced oncogenic transformation. Proc Natl Acad Sci U S A. 2011;108:13247-52 pubmed publisher

product information

master code :

1300

SKU :

1300/10

product name :

LFM-A13

unit size :

10 mg (also 50 mg)

description :

Potent, selective BTK inhibitor

target :

Brutons Tyrosine Kinase (BTK) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

360

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LFM-A13 is a potent and selective inhibitor of Bruton s tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 u M and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 u M.

top caption :

Potent, selective BTK inhibitor

extended description :

Potent, selective BTK inhibitor

chemical name text :

2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

formula :

C11H8Br2N2O2

formula text :

C11H8Br2N2O2

cas num :

62004-35-7

USD :

238 USD

product details :

Potent, selective BTK inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage