1295/10 | Tocris Bioscience 1295/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1295/10

catalog :

1295/10

quantity :

10 mg (also 50 mg)

price :

242 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Lemos J, Zhang G, Walsh T, Kirby L, Akanwa A, Brooks Kayal A, et al. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology. 2011;36:721-34 pubmed publisher
Kotak V, Takesian A, Sanes D. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. Cereb Cortex. 2008;18:2098-108 pubmed publisher

product information

master code :

1295

SKU :

1295/10

product name :

Loreclezole hydrochloride

unit size :

10 mg (also 50 mg)

description :

Subtype-selective GABAA modulator

target :

GABA-A Receptor Modulators

category :

Small Molecules

purity :

99%

observed molecular weight :

311

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of 2 or 3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric 1 GABAC receptors.

top caption :

Subtype-selective GABAA modulator

extended description :

Subtype-selective GABAA modulator

chemical name text :

(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride

formula :

C10H6Cl3N3.HCl

formula text :

C10H6Cl3N3.HCl

cas num :

2227372-56-5

USD :

242 USD

product details :

Subtype-selective GABAA modulator

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage