product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1290/10
catalog :
1290/10
quantity :
10 mg (also 50 mg)
price :
130 USD
more info or order :
citations: 23
Reference
Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
Kim J, Nam B, Choi Y, Kim S, Lee J, Sung K, et al. Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation. Cancer Res. 2018;78:4482-4496 pubmed publisher
Sharma M, Dierkes T, Sajikumar S. Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell. 2017;16:1062-1072 pubmed publisher
Li Q, Navakkode S, Rothkegel M, Soong T, Sajikumar S, Korte M. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114:5527-5532 pubmed publisher
Tom Dieck S, Kochen L, Hanus C, Heumüller M, Bartnik I, Nassim Assir B, et al. Direct visualization of newly synthesized target proteins in situ. Nat Methods. 2015;12:411-4 pubmed publisher
Zhao W, Chuang S, Young S, Bianchi R, Wong R. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. J Neurosci. 2015;35:308-15 pubmed publisher
Basu S, Rajakaruna S, Reyes B, Van Bockstaele E, Menko A. Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells. Autophagy. 2014;10:1193-211 pubmed publisher
Wang C, Held R, Hall B. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS ONE. 2013;8:e83941 pubmed publisher
Dobrikov M, Shveygert M, Brown M, Gromeier M. Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. Mol Cell Biol. 2014;34:439-51 pubmed publisher
Ramiro Cortés Y, Israely I. Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression. PLoS ONE. 2013;8:e71155 pubmed publisher
Ma T, Trinh M, Wexler A, Bourbon C, Gatti E, Pierre P, et al. Suppression of eIF2? kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013;16:1299-305 pubmed publisher
Valentine C, Zhang H, Phuan P, Nguyen J, Verkman A, Haggie P. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014;16:1-14 pubmed publisher
Bernard P, Castano A, O Leary H, Simpson K, Browning M, Benke T. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013;59:1-17 pubmed publisher
Liu M, Kang S, Shi T, Koga K, Zhang M, Collingridge G, et al. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol. 2013;110:505-21 pubmed publisher
Gouet C, Aburto B, Vergara C, Sanhueza M. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII. PLoS ONE. 2012;7:e49293 pubmed publisher
Tom Dieck S, Müller A, Nehring A, Hinz F, Bartnik I, Schuman E, et al. Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging. Curr Protoc Cell Biol. 2012;Chapter 7:Unit7.11 pubmed publisher
Fortin D, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach V, et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci. 2012;32:8127-37 pubmed publisher
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Zhao W, Chuang S, Bianchi R, Wong R. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 2011;31:725-34 pubmed publisher
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product information
master code :
1290
SKU :
1290/10
product name :
Anisomycin
unit size :
10 mg (also 50 mg)
description :
JNK, SAPK and p38 activator
target :
JNK/c-jun Activators
category :
Small Molecules
purity :
98%
observed molecular weight :
265.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Anisomycin is a protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
top caption :
JNK, SAPK and p38 activator
extended description :
JNK, SAPK and p38 activator
chemical name text :
(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
formula :
C14H19NO4
formula text :
C14H19NO4
cas num :
22862-76-6
USD :
130 USD
product details :
JNK, SAPK and p38 activator
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK