KT 5823 | Tocris Bioscience 1289 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KT 5823

catalog :

1289

quantity :

100 ug

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Livingstone R, Elder M, Barrett M, Westlake C, Peppercorn K, Tate W, et al. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 2019;12:198 pubmed publisher
Kuo H, Lai Y, Wu J, Lee K, Chu C, Chen I, et al. A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci. 2013;10:64-72 pubmed publisher
Becker J, Chatterjee S, Robinson T, Bennett J, Pan kov D, Galindo C, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014;141:335-45 pubmed publisher
Pulkkinen V, Manson M, Säfholm J, Adner M, Dahlen S. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol. 2012;303:L956-66 pubmed publisher
Giricz Z, Gorbe A, Pipis J, Burley D, Ferdinandy P, Baxter G. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. Br J Pharmacol. 2009;158:1495-502 pubmed publisher

product information

brand :

Tocris

master code :

1289

SKU :

1289/100U

product name :

KT 5823

description :

Selective protein kinase G inhibitor

target :

Protein Kinase G Inhibitors

category :

Small Molecules

unit size :

100 ug

purity :

98%

observed molecular weight :

495.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of protein kinase G (Ki values are 0.23, 4 and 10 u M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 u M.

catalog number base :

1289

product keywords :

Selective protein kinases G inhibitors inhibits PKG cGMP KT5823 Protein Kinase G 1289,

extended description :

Selective protein kinase G inhibitor

chemical name text :

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

formula :

C 29 H 25 N 3 O 5

formula text :

C29H25N3O5

cas num :

126643-37-6

2020 USD :

203

2021 USD :

212 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage