1289/100U | Tocris Bioscience 1289/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1289/100U

catalog :

1289/100U

quantity :

100 ug

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Jayabal P, Zhou F, Ma X, Bondra K, Blackman B, Weintraub S, et al. Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma. Cell Rep. 2023;42:112103 pubmed publisher
Livingstone R, Elder M, Barrett M, Westlake C, Peppercorn K, Tate W, et al. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 2019;12:198 pubmed publisher
Minami K, Liu S, Liu Y, Chen A, Wan Q, Na S, et al. Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis. Sci Rep. 2017;7:45686 pubmed publisher
Kuo H, Lai Y, Wu J, Lee K, Chu C, Chen I, et al. A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci. 2013;10:64-72 pubmed publisher
Becker J, Chatterjee S, Robinson T, Bennett J, Pan kov D, Galindo C, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014;141:335-45 pubmed publisher
Pulkkinen V, Manson M, Säfholm J, Adner M, Dahlen S. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol. 2012;303:L956-66 pubmed publisher
Cheung A, Newland P, Zaben M, Attard G, Gray W. Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide y on postnatal hippocampal precursor cells. J Biol Chem. 2012;287:20187-96 pubmed publisher
Giricz Z, Gorbe A, Pipis J, Burley D, Ferdinandy P, Baxter G. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. Br J Pharmacol. 2009;158:1495-502 pubmed publisher

product information

master code :

1289

SKU :

1289/100U

product name :

KT 5823

unit size :

100 ug

description :

Selective protein kinase G inhibitor

target :

Protein Kinase G Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

495.53

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and 10 u M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 u M.

top caption :

Selective protein kinase G inhibitor

extended description :

Selective protein kinase G inhibitor

chemical name text :

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

formula :

C29H25N3O5

formula text :

C29H25N3O5

cas num :

126643-37-6

USD :

267 USD

product details :

Selective protein kinase G inhibitor

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage