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company name :
Tocris Bioscience
product type :
chemical
product name :
1288/100U
catalog :
1288/100U
quantity :
100 ug
price :
267 USD
more info or order :
citations: 32
Reference
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Salinas F, Nebreda A, Vázquez L, Gentilini M, Marini V, Benedetti M, et al. Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs. Antiviral Res. 2020;179:104817 pubmed publisher
Vaden J, Banumurthy G, Gusarevich E, Overstreet Wadiche L, Wadiche J. The readily-releasable pool dynamically regulates multivesicular release. elife. 2019;8: pubmed publisher
Xu H, Rajsombath M, Weikop P, Selkoe D. Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. EMBO Mol Med. 2018;10: pubmed publisher
Patra K, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, et al. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 2018;20:811-822 pubmed publisher
Cruz J, Hupper N, Wilson L, Concannon J, Wang Y, Oberhauser B, et al. Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. J Biol Chem. 2018;293:11837-11849 pubmed publisher
Weng W, Chen Y, Wang M, Zhuang Y, Behnisch T. Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms. Front Cell Neurosci. 2016;10:247 pubmed
Cornelison L, Hawkins J, Durham P. Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons. Neuroscience. 2016;339:491-501 pubmed publisher
Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, et al. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. elife. 2016;5:e13185 pubmed publisher
Li X, Rhee D, Malhotra R, Mayeur C, Hurst L, Ager E, et al. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016;126:389-401 pubmed publisher
Smith M, Wilson R, O Brien S, Tufarelli C, Anderson S, O Sullivan S. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. PLoS ONE. 2015;10:e0136546 pubmed publisher
Merino B, Quesada I, Hernández Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, et al. Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 2015;5:10256 pubmed publisher
Parnell E, Koschinski A, Zaccolo M, Cameron R, Baillie G, Baillie G, et al. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochim Biophys Acta. 2015;1853:1749-58 pubmed publisher
Belgacem Y, Borodinsky L. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A. 2015;112:4140-5 pubmed publisher
Brignell J, Perry M, Nelson C, Willets J, Challiss R, Davies N. Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. PLoS ONE. 2015;10:e0121285 pubmed publisher
Thakran S, Zhang Q, Morales Tirado V, Steinle J. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. Invest Ophthalmol Vis Sci. 2014;56:177-84 pubmed publisher
Campos C, Shiina H, Ritter R. Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist. J Neurosci. 2014;34:12636-45 pubmed publisher
Liu M, Zhuo M. Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 2014;10:1 pubmed publisher
Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, et al. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process. J Biol Chem. 2013;288:31139-53 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Blasic J, Brown R, Robinson P. Phosphorylation of mouse melanopsin by protein kinase A. PLoS ONE. 2012;7:e45387 pubmed publisher
Than A, Cheng Y, Foh L, Leow M, Lim S, Chuah Y, et al. Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways. Mol Cell Endocrinol. 2012;362:227-41 pubmed publisher
Guo Y, Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 2012;318:2004-13 pubmed publisher
Nakao T, Tsujikawa M, Notomi S, Ikeda Y, Nishida K. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS ONE. 2012;7:e32472 pubmed publisher
Van Hook M, Wong K, Berson D. Dopaminergic modulation of ganglion-cell photoreceptors in rat. Eur J Neurosci. 2012;35:507-18 pubmed publisher
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product information
master code :
1288
SKU :
1288/100U
product name :
KT 5720
unit size :
100 ug
description :
Selective protein kinase A inhibitor
target :
Protein Kinase A Inhibitors
category :
Small Molecules
purity :
97%
observed molecular weight :
537.61
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki 2 u M). Reversibly arrests human skin fibroblasts in the G1 phase.
top caption :
Selective protein kinase A inhibitor
extended description :
Selective protein kinase A inhibitor
chemical name text :
(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
formula :
C32H31N3O5
formula text :
C32H31N3O5
cas num :
108068-98-0
USD :
267 USD
product details :
Selective protein kinase A inhibitor
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK