1285/100U | Tocris Bioscience 1285/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1285/100U

catalog :

1285/100U

quantity :

100 ug

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Valvezan A, Turner M, Belaid A, Lam H, Miller S, McNamara M, et al. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. 2017;32:624-638.e5 pubmed publisher
Mayer C, Gazumyan A, Kara E, Gitlin A, Golijanin J, Viant C, et al. The microanatomic segregation of selection by apoptosis in the germinal center. Science. 2017;358: pubmed publisher
Hejna M, Jorapur A, Song J, Judson R. High accuracy label-free classification of single-cell kinetic states from holographic cytometry of human melanoma cells. Sci Rep. 2017;7:11943 pubmed publisher
Xu B, Xu M, Tian Y, Yu Q, Zhao Y, Chen X, et al. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discov. 2017;3:16096 pubmed publisher
Hayes T, Benaich N, Goldie S, Sipilä K, Ames Draycott A, Cai W, et al. Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation. Cancer Lett. 2016;383:106-114 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
Gramlich O, Burand A, Brown A, Deutsch R, Kuehn M, Ankrum J. Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy. Sci Rep. 2016;6:26463 pubmed publisher
Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed publisher
Piccart E, Courtney N, Branch S, Ford C, Beckstead M. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015;35:11144-52 pubmed publisher
Sonamoto R, Kii I, Koike Y, Sumida Y, Kato Sumida T, Okuno Y, et al. Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Sci Rep. 2015;5:12728 pubmed publisher
O Donnell L, Henkins K, Kulkarni A, Matullo C, Balachandran S, Pattisapu A, et al. Interferon gamma induces protective non-canonical signaling pathways in primary neurons. J Neurochem. 2015;135:309-22 pubmed publisher
Dobson K, Jackson C, Balakrishnan S, Bellamy T. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. PLoS ONE. 2015;10:e0125974 pubmed publisher
Faulkner R, Wishard T, Thompson C, Liu H, Cline H. FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. Eneuro. 2015;2:e0055 pubmed
Barcomb K, Coultrap S, Bayer K. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013;84:834-43 pubmed publisher
Jackson T, Verrier J, Drabek T, Janesko Feldman K, Gillespie D, Uray T, et al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013;347:516-28 pubmed publisher
Valentine C, Zhang H, Phuan P, Nguyen J, Verkman A, Haggie P. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014;16:1-14 pubmed publisher
Schonbrunn E, Betzi S, Alam R, Martin M, Becker A, Han H, et al. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem. 2013;56:3768-82 pubmed publisher
Kawamoto E, Gleichmann M, Yshii L, Lima L, Mattson M, Scavone C. Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res. 2012;45:58-67 pubmed
Valero M, Fagundes D, Grasa L, Arruebo M, Plaza M, Murillo M. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin. 2011;32:487-94 pubmed publisher
Kondo K, Obitsu S, Ohta S, Matsunami K, Otsuka H, Teshima R. Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition. J Biol Chem. 2010;285:13079-91 pubmed publisher
Chen B, Nelson D, Sadovsky Y. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem. 2006;281:2764-72 pubmed

product information

master code :

1285

SKU :

1285/100U

product name :

Staurosporine

unit size :

100 ug

description :

Non-selective protein kinase inhibitor

target :

Broad Spectrum Protein Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

466.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Staurosporine is a broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C, p60v-src tyrosine protein kinase, protein kinase A, and CaM kinase II (IC50 values are 3nM, 6 nM, 7 nM and 20 nM, respectively). Staurosporine reduces nuclear myosin heavy chain 9 phosphorylation which inhibits gastric cancer cell progression in transgenic mouse models. Staurosporine inhibits cell viability and promotes apoptosis in oral and pancreatic cancer cells. Staurosporine also enhances efficiency of lentiviral transduction of human hematopoietic stem and progenitor cells by 2-fold, induces dopaminergic axonal outgrowth in vitro and triggers mitophagy. Staurosporine has high affinity (Kd = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Staurosporine and leads to robust reporter gene expressions in B. subtilis . . Staurosporine synthesized to Ancillary Material Grade is also available.

extended description :

Non-selective protein kinase inhibitor

chemical name text :

[9S-(9 ,10 ,11 ,13 )]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3 ,2 ,1 -lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

formula :

C28H26N4O3

formula text :

C28H26N4O3

cas num :

62996-74-1

USD :

197 USD

product details :

Non-selective protein kinase inhibitor

alt names :

AM-2282

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage